Hemphill H E, Gage I, Zahler S A, Korman R Z
Can J Microbiol. 1980 Nov;26(11):1328-33. doi: 10.1139/m80-220.
Cultures of Bacillus subtilis lysogenic for the temperature bacteriophage SP beta release "betacin", a bacteriocinlike substance that inhibits B. subtilis strains which do not carry this phage. Production of betacin is blocked by mutations in the bet gene on the prophage and a second phage gene, tol, is apparently involved in making the lysogen itself tolerant to betacin. Mutations in a bacterial gene betR, located on the B. subtilis chromosome between metC and pyrD, render nonlysogens tolerant to betacin.
对温度噬菌体SPβ呈溶原性的枯草芽孢杆菌培养物会释放出“β菌素”，这是一种类似细菌素的物质，可抑制未携带该噬菌体的枯草芽孢杆菌菌株。β菌素的产生被原噬菌体上bet基因的突变所阻断，而另一个噬菌体基因tol显然参与使溶原菌自身对β菌素产生耐受性。位于枯草芽孢杆菌染色体上metC和pyrD之间的细菌基因betR发生突变，可使非溶原菌对β菌素产生耐受性。
