Naot Y, Davidson S, Lindenbaum E S
J Infect Dis. 1981 Jan;143(1):55-62. doi: 10.1093/infdis/143.1.55.
Mitogenic preparations of nonviable lysed cells and purified membranes of Mycoplasma pulmonis induced interstitial pneumonia and tracheitis after intranasal administration to pathogen-free rats. The pneumonia, characterized by peribronchial, perivascular, and alveolar wall infiltration by lymphocytes, was indistinguishable from that produced by viable M. pulmonis. Both pathologic and mitogenic effects were significanlty reduced by prior treatment of membranes with heat or proteolytic enzyme. Intranasal administration of the thymus-derived-cell mitogen, concanavalin A, produced interstitial pneumonia but not tracheitis. These results indicate a correlation of mitogenicity and pathogenicity and suggest that activation of thymus-derived lymphocytes is the major cause of the pneumonia resulting from infections with M. pulmonis.
将肺炎支原体的无活性裂解细胞和纯化膜的促有丝分裂制剂经鼻内给药给无菌大鼠后，可诱发间质性肺炎和气管炎。这种肺炎的特征是淋巴细胞浸润支气管周围、血管周围和肺泡壁，与活的肺炎支原体所引起的肺炎无法区分。通过预先用加热或蛋白水解酶处理膜，病理和促有丝分裂作用均显著降低。经鼻内给予胸腺来源细胞促有丝分裂原刀豆球蛋白A，可产生间质性肺炎，但不会引起气管炎。这些结果表明促有丝分裂性与致病性之间存在关联，并提示胸腺来源淋巴细胞的激活是肺炎支原体感染所致肺炎的主要原因。
