各种支原体菌株和种类对淋巴细胞的激活作用。
Lymphocyte activation by various Mycoplasma strains and species.
作者信息
Naot Y, Tully J G, Ginsburg H
出版信息
Infect Immun. 1977 Nov;18(2):310-7. doi: 10.1128/iai.18.2.310-317.1977.
The capacity of various mycoplasma strains and species to induce lymphocyte transformation in vitro was studied. Of six strains of Mycoplasma pulmonis studied, five displayed mitogenic activity with rat lymphocytes. Among those M. pulmonis strains, our MP15 isolate and the Negroni strain exhibited particularly potent mitogenic capacity. The murine mycoplasmas M. neurolyticum and M. arthritidis shared this mitogenicity for rat lymphocytes. However, the human mycoplasmas M. fermentans, M. pneumoniae, M. hominis, M. orale, and Acholeplasma laidlawii did not activate rat lymphocytes. Lymphocytes obtained from germfree rats were activated to the same extent as those from animals bred under conventional conditions. The mitogenic potency exhibited by mycoplasma was not restricted to infective microorganisms, and preparations of killed mycoplasma particles exerted an extensive lymphocyte transformation. The data show that the mitogenic activity of mycoplasmas is not confined to a single mycoplasma isolate and that it acts in a nonspecific manner.
研究了各种支原体菌株和种类在体外诱导淋巴细胞转化的能力。在所研究的6株肺支原体中，有5株对大鼠淋巴细胞表现出促有丝分裂活性。在这些肺支原体菌株中，我们分离出的MP15菌株和内格罗尼菌株表现出特别强的促有丝分裂能力。溶神经支原体和关节炎支原体这两种鼠支原体对大鼠淋巴细胞也具有这种促有丝分裂性。然而，人型支原体、肺炎支原体、人型支原体、口腔支原体和解脲脲原体等人类支原体以及莱氏无胆甾原体均未激活大鼠淋巴细胞。无菌大鼠获得的淋巴细胞与常规饲养动物的淋巴细胞被激活的程度相同。支原体表现出的促有丝分裂能力并不局限于感染性微生物，灭活支原体颗粒制剂也能广泛诱导淋巴细胞转化。数据表明，支原体的促有丝分裂活性并不局限于单一的支原体分离株，且其作用方式是非特异性的。
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