小鼠体内甲酰肼致癌作用
Formylhydrazine carcinogenesis in mice.
作者信息
Toth B
出版信息
Br J Cancer. 1978 Jun;37(6):960-4. doi: 10.1038/bjc.1978.140.
Abstract
Administration of 0.125% formylhydrazine in drinking water to 6-week-old randomly bred Swiss albino mice for life, induced lung tumours. Compared to untreated controls, the lung-tumour incidence rose from 15 to 94% in the females and from 22 to 100% in the males. The treatment had no detectable tumorigenic effect in other organs.
摘要
给6周龄的随机繁殖的瑞士白化小鼠终生饮用含0.125%甲酰肼的水，可诱发肺部肿瘤。与未处理的对照组相比，雌性小鼠的肺部肿瘤发生率从15%升至94%，雄性小鼠从22%升至100%。该处理在其他器官未检测到致瘤作用。
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