小鼠体内甲酰肼致癌作用
Formylhydrazine carcinogenesis in mice.
作者信息
Toth B
出版信息
Br J Cancer. 1978 Jun;37(6):960-4. doi: 10.1038/bjc.1978.140.
Abstract
Administration of 0.125% formylhydrazine in drinking water to 6-week-old randomly bred Swiss albino mice for life, induced lung tumours. Compared to untreated controls, the lung-tumour incidence rose from 15 to 94% in the females and from 22 to 100% in the males. The treatment had no detectable tumorigenic effect in other organs.
摘要
给6周龄的随机繁殖的瑞士白化小鼠终生饮用含0.125%甲酰肼的水，可诱发肺部肿瘤。与未处理的对照组相比，雌性小鼠的肺部肿瘤发生率从15%升至94%，雄性小鼠从22%升至100%。该处理在其他器官未检测到致瘤作用。
相似文献
1
Formylhydrazine carcinogenesis in mice.小鼠体内甲酰肼致癌作用
Br J Cancer. 1978 Jun;37(6):960-4. doi: 10.1038/bjc.1978.140.
2
1,2-diallylhydrazine dihydrochloride carcinogenesis in mice.1,2 - 二烯丙基肼二盐酸盐在小鼠体内的致癌作用
Oncology. 1982;39(2):104-8. doi: 10.1159/000225616.
3
Tumorigenesis by N-n-propyl-N-formylhydrazine in mice.N-正丙基-N-甲酰肼在小鼠体内的肿瘤发生
Br J Cancer. 1980 Dec;42(6):922-8. doi: 10.1038/bjc.1980.341.
4
Tumorigenic action of N-n-butyl-N-formylhydrazine in mice.N-正丁基-N-甲酰肼对小鼠的致瘤作用。
Carcinogenesis. 1980 Jul;1(7):589-93. doi: 10.1093/carcin/1.7.589.
5
Carcinogenesis by a single dose of N-methyl-N-formylhydrazine.单次剂量的N-甲基-N-甲酰肼致癌作用。
J Toxicol Environ Health. 1980 May;6(3):577-84. doi: 10.1080/15287398009529875.
6
Tumorigenesis with 1,1-diallylhydrazine in mice.
Anticancer Res. 1981;1(5):259-62.
7
Nicotinic acid hydrazide carcinogenesis in mice.烟酰肼在小鼠体内的致癌作用。
Oncology. 1981;38(2):106-9. doi: 10.1159/000225532.
8
Tumorigenicity of tetramethylhydrazine hydrochloride in Swiss mice.
J Natl Cancer Inst. 1976 Nov;57(5):1179-83. doi: 10.1093/jnci/57.5.1179.
9
Lung tumorigenesis by 1,2-diformylhydrazine in mice.小鼠中1,2 - 二甲酰肼诱导的肺肿瘤发生
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1978 Aug 24;92(1):11-6. doi: 10.1007/BF00284090.
10
Tumorigenic effect of 1-hydrazinophthalazine hydrochloride in mice.盐酸1-肼基酞嗪对小鼠的致瘤作用。
J Natl Cancer Inst. 1978 Nov;61(5):1363-5. doi: 10.1093/jnci/61.5.1363.
引用本文的文献
1
Actual new cancer-causing hydrazines, hydrazides, and hydrazones.实际的新型致癌肼类、酰肼类和腙类化合物。
J Cancer Res Clin Oncol. 1980;97(2):97-108. doi: 10.1007/BF00409895.
2
1,2-di-n-butylhydrazine dihydrochloride carcinogenesis in mice.1,2 - 二正丁基肼二盐酸盐对小鼠的致癌作用
Experientia. 1981 Jul 15;37(7):773-5. doi: 10.1007/BF01967972.
3
A carcinogenic potency database of the standardized results of animal bioassays.一个关于动物生物测定标准化结果的致癌效力数据库。
Environ Health Perspect. 1984 Dec;58:9-319. doi: 10.1289/ehp.84589.
4
Carcinogenesis by pentanal methylformylhydrazone of Gyromitra esculenta in mice.
Mycopathologia. 1987 May;98(2):83-9. doi: 10.1007/BF00437293.
5
Tumor induction with hexanal methylformylhydrazone of Gyromitra esculenta.用鹿花菌己醛甲基甲酰腙诱导肿瘤
Mycopathologia. 1991 Aug;115(2):65-71. doi: 10.1007/BF00436794.
6
Lung tumorigenesis by 1,2-diformylhydrazine in mice.小鼠中1,2 - 二甲酰肼诱导的肺肿瘤发生
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1978 Aug 24;92(1):11-6. doi: 10.1007/BF00284090.
本文引用的文献
1
2
[Gyromitrin, the poison of Gyromitra esculenta. 16. On the fungi contents].[鹿花菌素，鹿花菌的毒素。16. 关于真菌成分]
Arch Pharm Ber Dtsch Pharm Ges. 1968 Apr;301(4):294-305. doi: 10.1002/ardp.19683010410.
3
4
Hydrazine, methylhydrazine and methylhydrazine sulfate carcinogenesis in Swiss mice. Failure of ammonium hydroxide to interfere in the development of tumors.肼、甲基肼和硫酸甲基肼在瑞士小鼠中的致癌作用。氢氧化铵对肿瘤发生发展的干预失败。
Int J Cancer. 1972 Jan 15;9(1):109-18. doi: 10.1002/ijc.2910090113.
5
1-Carbamyl-2-phenylhydrazine tumorigenesis in Swiss mice. Morphology of lung adenomas.1-氨基甲酰基-2-苯基肼在瑞士小鼠体内的肿瘤发生。肺腺瘤的形态学。
J Natl Cancer Inst. 1974 Jan;52(1):241-51. doi: 10.1093/jnci/52.1.241.
6
7
1,1-Dimethylhydrazine (unsymmetrical) carcinogenesis in mice. Light microscopic and ultrastructural studies on neoplastic blood vessels.1,1 - 二甲基肼（不对称）对小鼠的致癌作用。肿瘤血管的光镜和超微结构研究。
J Natl Cancer Inst. 1973 Jan;50(1):181-94. doi: 10.1093/jnci/50.1.181.
8
Synthetic and naturally occurring hydrazines as possible cancer causative agents.合成及天然存在的肼类化合物作为潜在的致癌因素。
Cancer Res. 1975 Dec;35(12):3693-7.
9
Tumorigenic agents in unburned processed tobacco: N-nitrosodiethanolamine and 1,1-dimethylhydrazine.未燃烧的加工烟草中的致瘤物质：N-亚硝基二乙醇胺和1,1-二甲基肼。
Cancer Lett. 1977 Jan;2(3):125-31. doi: 10.1016/s0304-3835(77)80001-3.
10
Naturally occurring compounds Containing a nitrogen-nitrogen bond.含有氮-氮键的天然存在的化合物。
Lloydia. 1977 Jul-Aug;40(4):307-21.
Zotero 插件