Hachinski V C, Olesen J, Norris J W, Larsen B, Enevoldsen E, Lassen N A
Can J Neurol Sci. 1977 Nov;4(4):245-9. doi: 10.1017/s0317167100025063.
Clinical and angiographic findings in migraine are briefly reviewed in relation to cerebral hemodynamic changes shown by regional cerebral blood flow (rCBF) studies. Three cases of migraine studied by the intracarotid xenon 133 method during attacks are reported. In classic migraine, with typical prodromal symptoms, a decrease in cerebral blood flow has been demonstrated during the aura. Occasionally, this flow decrease persists during the headache phase. In common migraine, where such prodromata are not seen, a flow decrease has not been demonstrated. During the headache phase of both types of migraine, rCBF has usually been found to be normal or in the high range of normal values. The high values may represent postischemic hyperemia, but are probably more frequently secondary to arousal caused by pain. Thus, during the headache phase rCBF may be subnormal, normal or high. These findings do not exclude the possibility of distension of the larger intracranial arteries during migraine headache, but the angiographic evidence, however limited, does not support this speculation.
结合局部脑血流量（rCBF）研究显示的脑血流动力学变化，对偏头痛的临床和血管造影表现进行简要回顾。报告了3例发作期采用颈内注射氙133方法研究的偏头痛病例。在典型偏头痛伴典型前驱症状的情况下，已证实在先兆期脑血流量减少。偶尔，这种血流减少在头痛期持续存在。在普通偏头痛中，未见此类前驱症状，未证实有血流减少。在两种类型偏头痛的头痛期，通常发现rCBF正常或处于正常数值的高限。高值可能代表缺血后充血，但可能更常见的是继发于疼痛引起的觉醒。因此，在头痛期rCBF可能低于正常、正常或高于正常。这些发现并不排除偏头痛发作时较大颅内动脉扩张的可能性，但血管造影证据，无论多么有限，都不支持这一推测。
