7,2-二甲基苯并[a]蒽的微生物转化
Microbial transformations of 7,2-dimethylbenz[a]anthracene.
作者信息
Wu J, Wong L K
出版信息
Appl Environ Microbiol. 1981 Mar;41(3):843-5. doi: 10.1128/aem.41.3.843-845.1981.
Abstract
Microbial transformations of 7,12-dimethylbenz[a]anthracene, a carcinogenic polycyclic aromatic hydrocarbon, in cultures of Pseudomonas aeruginosa and Penicillium notatum were studied by high performance liquid chromatographic separation of metabolic fractions followed by gas chromatographic-mass spectrometric analysis of the metabolites. Two methyl-hydroxylated metabolites were identified in each of the incubations. The metabolic activation of the polycyclic aromatic hydrocarbon suggests a possible involvement of microorganisms in environmental carcinogenesis.
摘要
通过对代谢组分进行高效液相色谱分离，然后对代谢产物进行气相色谱-质谱分析，研究了铜绿假单胞菌和点青霉培养物中致癌多环芳烃7,12-二甲基苯并[a]蒽的微生物转化。在每次培养中均鉴定出两种甲基羟基化代谢产物。多环芳烃的代谢活化表明微生物可能参与环境致癌作用。
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