Miller S D, Thompson H S
Br J Ophthalmol. 1978 Jul;62(7):495-500. doi: 10.1136/bjo.62.7.495.
A thin slit-lamp beam illuminating the pupil margin produces clearly visible pupil oscillations. These oscillations can be timed with a stopwatch, thus producing a measurement of the "edge-light" pupil cycle time'. The pupil cycle time is remarkably stable in various testing situations and is repeatable within about +/- 3% over extended periods of time. Expected normal distribution and 95% confidence intervals are given in Table 3. When the iris muscles are normally innervated and responsive, the pupil cycle time is dependent on the speed of nerve conduction and the number and strength of optic nerve impulses. Only 5% of normal persons aged 12 to 50 years are expected to have a pupil cycle time in either eye longer than 954 ms or a difference in pupil cycle time between the two eyes longer than 70 ms.
一束薄的裂隙灯光束照射瞳孔边缘会产生清晰可见的瞳孔振荡。这些振荡可用秒表计时，从而得出“边缘光”瞳孔周期时间的测量值。瞳孔周期时间在各种测试情况下都非常稳定，并且在较长时间段内可重复，误差约为±3%。表3给出了预期的正态分布和95%置信区间。当虹膜肌肉正常受神经支配且有反应时，瞳孔周期时间取决于神经传导速度以及视神经冲动的数量和强度。预计12至50岁的正常人中，只有5%的人单眼瞳孔周期时间会超过954毫秒，或者两眼瞳孔周期时间差异会超过70毫秒。
