Effect of indomethacin upon angiotensin-induced changes in blood pressure and plasma aldosterone in normal man.

The effect of indomethacin (75 mg/day for 3 days) on the response to i.v. angiotensin II was investigated in eight healthy, sodium-repleted, male subjects. Indomethacin reduced the release of aldosterone during the i.v. administration of angiotensin II (5, 10 and 20 ng kg-1 min-1), whereas the pressor response to angiotensin II and to succinamyl1-val5-phenylglycineacetate8-angiotensin II, an agonistic angiotensin II-analogue, was increased. Plasma renin concentration was reduced following treatment with indomethacin. These data confirm the modulatory influence of endogenous prostaglandins upon the vasoconstrictor effect of angiotensin II and could suggest a direct interference of prostaglandins with the secretion of aldosterone.