Kassell N F, Hitchon P W, Gerk M K, Sokoll M D, Hill T R
J Neurosurg. 1981 May;54(5):615-9. doi: 10.3171/jns.1981.54.5.0615.
In 13 dogs the response of the cerebral circulation to changes in PaCO2 ranging from 20 to 60 torr was studied before and after administration of high doses of sodium thiopental. Infusion of sufficient barbiturate to produce 30- to 60-second burst suppression in the electroencephalogram was associated with a profound degree of cerebral vasoconstriction, equivalent to that produced by hypocapnia with PaCO2 = 20 torr. Furthermore, once sodium thiopental was administered, no significant difference in cerebral blood flow (CBF) or vascular resistance (CVR) was noted between PaCO2 of 30 and 20 torr. However, changes of approximately 15% in CBF and 30% in CVR were noted between PaCO2 at 40 and 20 torr. These data suggest that hyperventilation of PaCO2 of less than 30 torr may not effectively increase the degree of cerebral vasoconstriction in these circumstances.
在13只狗身上，研究了大剂量硫喷妥钠给药前后，脑循环对动脉血二氧化碳分压（PaCO2）从20至60托变化的反应。输注足够的巴比妥酸盐以使脑电图产生30至60秒的爆发抑制，这与深度脑血管收缩有关，等同于PaCO2 = 20托的低碳酸血症所产生的收缩程度。此外，一旦给予硫喷妥钠，在PaCO2为30和20托之间，未观察到脑血流量（CBF）或血管阻力（CVR）有显著差异。然而，在PaCO2为40和20托之间，CBF有大约15%的变化，CVR有30%的变化。这些数据表明，在这些情况下，将PaCO2过度通气至低于30托可能无法有效增加脑血管收缩程度。
