Miyamoto U
Acta Obstet Gynaecol Jpn. 1981 May;33(5):711-3.
In order to elucidate the sex difference of cord blood hormones, concentration of hCG, hCG-alpha, hCG-beta, hLH, hFSH, estradiol (E2), progesterone (P) and testosterone (T) in cord veins were assayed by radioimmunoassays. Mean concentrations of cord vein hCG, hCG-alpha and hLH were significantly higher in female than in male, but those of hFSH and T were significantly higher in male than in female. Male and female cord vein levels of hCG-beta, E2 and P were not significantly different and hCG-beta and hFSh levels in cord veins at term are low in both sexes. These lower concentrations of hLH in male may be a result of the feedback inhibitory action by the higher concentrations of T in male at term. These data suggest a sex difference in the synthesis and secretion of gonadotropins by the pituitary gland in the human foetus at term.
为了阐明脐血激素的性别差异，采用放射免疫分析法检测脐静脉中hCG、hCG-α、hCG-β、hLH、hFSH、雌二醇（E2）、孕酮（P）和睾酮（T）的浓度。脐静脉hCG、hCG-α和hLH的平均浓度在女性中显著高于男性，但hFSH和T的平均浓度在男性中显著高于女性。男性和女性脐静脉hCG-β、E2和P的水平无显著差异，足月时脐静脉中hCG-β和hFSh的水平在两性中均较低。男性中hLH浓度较低可能是足月时男性中较高浓度的T产生反馈抑制作用的结果。这些数据表明足月时人类胎儿垂体促性腺激素的合成和分泌存在性别差异。
