Furuhashi N, Fukaya T, Kono H, Tachibana Y, Shinkawa O, Takahashi T
Nihon Sanka Fujinka Gakkai Zasshi. 1981 Nov;33(11):1905-9.
Lutenizing hormone (LH-hCG), follicle stimulating hormone (FSH), beta-human chorionic gonadotropin (beta-hCG), estradiol, cortisol and testosterone were determined and correlated with each hormones in 62 cord sera (32 male and 35 female infants). Mean (+/- S.E.)male cord sera cortisol concentrations (36.2 +/- 3.9 ug/dl) were significantly (p less than 0.05) higher than that of female (24.1 +/- 3.7 ug/dl). Another hormones were not found significant sex difference. Regression analysis showed significant positive correlations between LH-hCG (r = 0.525, p less than 0.001) or beta-hCG (r = 0.461, p less than 0.005) levels and FSH levels in all cord sera (N = 67). In male cord sera, there were significant positive correlations between LH-hCG (r = 0.493, p less than 0.01) or beta-hCG (r = 0.485, p less than 0.01) levels and testosterone levels. There was a significant positive correlation (p less than 0.01) between estradiol levels and testosterone levels in female cord sera. These data suggest (1) the sex difference of cortisol levels which indicate the response for the stress during labor and delivery, (2) there was a significant sex difference in the maturation of the feed back mechanism in pituitary-gonadal axis.
检测了62份脐带血清（32例男婴和35例女婴）中的促黄体生成素（LH - hCG）、促卵泡生成素（FSH）、β - 人绒毛膜促性腺激素（β - hCG）、雌二醇、皮质醇和睾酮，并分析了各激素之间的相关性。男婴脐带血清皮质醇浓度均值（±标准误）为（36.2±3.9μg/dl），显著高于女婴（24.1±3.7μg/dl）（p＜0.05）。未发现其他激素存在显著的性别差异。回归分析显示，在所有脐带血清（N = 67）中，LH - hCG（r = 0.525，p＜0.001）或β - hCG（r = 0.461，p＜0.005）水平与FSH水平之间存在显著正相关。在男婴脐带血清中，LH - hCG（r = 0.493，p＜0.01）或β - hCG（r = 0.485，p＜0.01）水平与睾酮水平之间存在显著正相关。在女婴脐带血清中，雌二醇水平与睾酮水平之间存在显著正相关（p＜0.01）。这些数据表明：（1）皮质醇水平存在性别差异，这表明了分娩过程中对应激的反应；（2）垂体 - 性腺轴反馈机制的成熟存在显著性别差异。
