Ohi G, Seki H, Minowa K, Mizoguchi I, Sugimori F
Arch Toxicol. 1980 Dec;46(3-4):265-72. doi: 10.1007/BF00310443.
A single dose of lead acetate (either 30 mg/kg or 150 mg/kg) was intraperitoneally (i.p.) administered to adult feral pigeons, Columba livia var and the effects of calcium disodium ethylenediamine tetraacetate (CaNa2EDTA), (0, 150, 300, 600 mg/kg), administered i.p. twice a week in the ensuing period were observed. Lead acetate caused dose related mortality and decreases in weight, hematocrit and delta-aminolevulinic acid dehydratase activity (ALA-D). Acute toxicity of lead acetate in the pigeon, when given intraperitoneally, appeared approximately equivalent to that in the rat and mouse in terms of LD50. Blood lead (blood Pb) levels observed during the lethal stage were five to ten times less than those reported for chronic oral lead poisoning in the pigeon. Biological implications of elevated levels of blood Pb observed in the feral pigeon in the urban Tokyo area are discussed. CaNa2EDTA induced dose related recovery in ALA-D in 30 mg/kg group, and reduction of blood Pb levels in the group dosed with 150 mg/kg of lead acetate.
给成年野生家鸽（Columba livia var）腹腔注射（i.p.）单剂量醋酸铅（30毫克/千克或150毫克/千克），并观察随后每周两次腹腔注射乙二胺四乙酸二钠钙（CaNa2EDTA，0、150、300、600毫克/千克）的效果。醋酸铅导致与剂量相关的死亡率，并使体重、血细胞比容和δ-氨基乙酰丙酸脱水酶活性（ALA-D）降低。腹腔注射醋酸铅时，其对家鸽的急性毒性在半数致死剂量（LD50）方面似乎与大鼠和小鼠大致相当。致死阶段观察到的血铅（血液Pb）水平比家鸽慢性口服铅中毒报道的水平低五到十倍。讨论了东京市区野生家鸽血铅水平升高的生物学意义。CaNa2EDTA在30毫克/千克组中诱导ALA-D与剂量相关的恢复，并降低了腹腔注射150毫克/千克醋酸铅组的血铅水平。
