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[在决定性病灶影响下大脑皮质癫痫活动复合体的形成机制]

[Mechanism of formation of epileptic activity complexes in the cerebral cortex under the influence of a determinant focus].

作者信息

Kryzhanovskiĭ G N, Makul'kin R F, Shandra A A, Boĭko D V

出版信息

Biull Eksp Biol Med. 1978;86(7):14-9.

PMID:678643
Abstract

It was shown in the experiments on cats anesthetized by nembutal that by forming a hyperactive focus with a high level of excitation in the temporal cortex and a number of foci with a less higher level of the excitation in other parts of neocortex, it is possible to create a functional complex, working in a single routine, determined by the activity of hyperactive focus. The latter plays a role of a determinant structure. The inhibition of the determinant focus results in the disturbance of the epileptic complex. Focus nature has no sufficient importance in the realization of the following interrelations: both the determinant focus and dependent foci may be created by means of strychnin and penicillin, disturbing different forms of the inhibition. The results of our investigations evidence a common conception on the role of determinant structures in the activity of the nervous system.

摘要

在对用戊巴比妥麻醉的猫进行的实验中表明,通过在颞叶皮层形成具有高兴奋水平的多动灶以及在新皮层其他部位形成一些兴奋水平稍低的灶,可以创建一个功能复合体,该复合体按照由多动灶的活动所决定的单一程序工作。后者起着决定性结构的作用。抑制决定性灶会导致癫痫复合体的紊乱。在实现以下相互关系方面,灶的性质没有足够的重要性:决定性灶和从属灶都可以通过士的宁和青霉素产生,它们会干扰不同形式的抑制。我们的研究结果证明了关于决定性结构在神经系统活动中的作用的一个普遍概念。

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