Krasnovskaia I A
Biull Eksp Biol Med. 1978;86(7):3-5.
The supraoptic, paraventricular, and postoptic nuclei (SON, PVN, and PON, respectively) of the hypothalamus were studied under conditions of 3 months training of rats to hypoxia (exposure for 6 h daily in a low pressure chamber under 7600m of simulated altitude). All the three nuclei were activated during the first 5 days, and then the state of the SON cells normalized. Functional activity of the PVN and PON decreased (the nucleolar volume of the neurosecretory cells diminished to 70--80%, the amount of the neurosecretory substance in the cells and the posterior lobe of the hypophysis was reduced). Such a decreased activity of the PVN and PON persisted till the end of the experiment. A positive correlation of the thyroid epithelium height and the nucleolar volume of the PVN and PON cells was established for both the PVN (r=0.81, P less than 0.05) and the PON (r=0.82; P less than 0.05); no significant correlation was revealed for the SON (r=0.51; P less than 0.05). Thus, functional similarity of the PVN and the PON, and some peculiarities in the SON reaction under conditions of the experiment described was demonstrated.
对大鼠进行为期3个月的低氧训练（每天在模拟海拔7600米的低压舱中暴露6小时），在此条件下研究下丘脑的视上核、室旁核和视后核（分别为SON、PVN和PON）。在最初的5天里，所有这三个核均被激活，随后SON细胞的状态恢复正常。PVN和PON的功能活性降低（神经分泌细胞的核仁体积减小至70%-80%，细胞及垂体后叶中神经分泌物质的量减少）。PVN和PON的这种活性降低一直持续到实验结束。在PVN（r=0.81，P<0.05）和PON（r=0.82；P<0.05）中，均建立了甲状腺上皮高度与PVN和PON细胞的核仁体积之间的正相关；而在SON中未发现显著相关性（r=0.51；P<0.05）。因此，证明了PVN和PON的功能相似性，以及在所描述的实验条件下SON反应的一些特点。
