Gluckman S J, MacGregor R R
Blood. 1978 Sep;52(3):551-9.
Granulocyte mobilization into skin abrasions in human volunteers was significantly inhibited by acute alcohol intoxication (45,-800 cells in 8 hr versus 353,000 in normal controls). Alcohol applied locally did not inhibit granulocyte delivery, and protection of the abrasion against heat loss did not reduce the inhibited delivery in intoxicated volunteers. Intoxication inhibited granulocyte adherence and local mobilization in parallel. Alcohol administration to rabbits shifted granulocytes from marginal to circulating pool in a manner similar to epinephrine. Mobilization of bone marrow granulocytes by glucocorticoid or endotoxin administration was not inhibited by intoxication, nor did it prevent the endotoxin-induced shift of granulocytes from circulating to marginal pool.
急性酒精中毒显著抑制了人类志愿者皮肤擦伤处粒细胞的募集（8小时内为45 - 800个细胞，而正常对照组为353,000个）。局部应用酒精并未抑制粒细胞的输送，并且对擦伤处进行保暖也未减少中毒志愿者中受抑制的粒细胞输送。中毒同时抑制了粒细胞的黏附和局部募集。给兔子注射酒精会使粒细胞以类似于肾上腺素的方式从边缘池转移至循环池。中毒并未抑制糖皮质激素或内毒素诱导的骨髓粒细胞募集，也未阻止内毒素诱导的粒细胞从循环池向边缘池的转移。
