Riordan K K, Weiskopf R B, Townsley M I, Chadwick K R
Pflugers Arch. 1981 Apr;390(1):99-101. doi: 10.1007/BF00582720.
Decrease in hemoglobin oxygen saturation without change of true blood base-excess results in an increase in calculated base-excess because of differences in acidity between oxy- and deoxyhemoglobin. We have determined the mean +/- SE canine base-excess correction coefficient to be 0.43 +/- 0.01 mmol base per mmol heme, a value approximately 34% higher than the corresponding value for human hemoglobin.
