Luehrsen K R, Fox G E
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2150-4. doi: 10.1073/pnas.78.4.2150.
A five-helix secondary structural model is proposed for eukaryotic cytoplasmic 5S rRNA. All available sequence data are consistent with this model including those from Chlorella 5S rRNA whose sequence is revised by data included here. Various architectural features of eukaryotic 5S rRNA are summarized in terms of this secondary structural model. It is observed that previous failures to identify universal models for 5S rRNA secondary structure stem from significant differences in architecture between eukaryotic cytoplasmic and eubacterial 5S rRNAs. The usual four-helix model for eubacterial 5S rRNA secondary structure nevertheless does share several structural features with the five-helix model presented here for cytoplasmic 5S rRNA. It is thus likely that these two classes of 5S rRNA are the result of evolutionary divergence rather than convergence.
本文提出了真核细胞质5S rRNA的五螺旋二级结构模型。所有可用的序列数据均与该模型一致，包括来自小球藻5S rRNA的数据，其序列已根据本文所包含的数据进行了修订。真核5S rRNA的各种结构特征根据该二级结构模型进行了总结。据观察，先前未能确定5S rRNA二级结构的通用模型是由于真核细胞质和细菌5S rRNA在结构上存在显著差异。然而，细菌5S rRNA二级结构通常的四螺旋模型与本文提出的细胞质5S rRNA的五螺旋模型确实有几个结构特征相同。因此，这两类5S rRNA很可能是进化分歧而非趋同的结果。
