Gutman G A
Transplant Proc. 1981 Jun;13(2):1483-8.
Several features of the RI-1 system in the rat render it of special interest to the immunogeneticist. First, it remains the only kappa chain marker in a laboratory rodent. Second, the degree of structural divergence between the two known forms is unexpected for the products of allelic genes and raises interesting genetic and evolutionary questions. If they are truly allelic, what is the nature of the selective forces that have produced and maintained this polymorphism? If they are not allelic, what genetic structure and control mechanism can account for their allelic expression? The Australian Rattus group is clearly providing a valuable system for studying the nature of kappa chain diversity and evolution. In addition, the possibility of making laboratory crosses between forms that differ both phenotypically and karyologically provides the opportunity of establishing linkage relationships and chromosomal localization for RI-1 and many other biochemical loci.
大鼠RI - 1系统的几个特征使其成为免疫遗传学家特别感兴趣的对象。首先，它仍是实验室啮齿动物中唯一的κ链标记。其次，两种已知形式之间的结构差异程度对于等位基因的产物来说是出乎意料的，这引发了有趣的遗传和进化问题。如果它们真的是等位基因，那么产生并维持这种多态性的选择力的本质是什么？如果它们不是等位基因，什么样的遗传结构和控制机制可以解释它们的等位基因表达？澳大利亚家鼠种群显然为研究κ链多样性和进化的本质提供了一个有价值的系统。此外，在表型和核型上都不同的形式之间进行实验室杂交的可能性，为确定RI - 1和许多其他生化基因座的连锁关系和染色体定位提供了机会。
