[Effect of carcinogenic exposure and tumor growth on the sensitization of C3HA mouse lymphoid cells to normal cell antigens].

The reaction of indirect inhibition of peritoneal cell adherence to glass was used for a comparative study of the reactivity of lymph node cells of mice injected with the hepatocarcinogen DAB (4-dimethylaminoazobenzene) or with its non-carcinogenic analogue DEAB (4-diethylaminozobenzene, or with hepatoma 22a cells. The ability of regional lymph node cells to sensibilization towards normal cellular antigens decreased following the DAB treatment stronger and for a longer time period than that DEAB treatment. To the contrary, the growth or hepatoma 22a was accompanied by an appreciable sensibilization of cells of the regional lymph nodes. The results obtained are discussed in context of of the problem of immune surveillance of cytodifferentiation.