Imada A, Nozaki Y, Kintaka K, Okonogi K, Kitano K, Harada S
J Antibiot (Tokyo). 1980 Dec;33(12):1417-24. doi: 10.7164/antibiotics.33.1417.
C-19393 S2 and H2 are new carbapenem antibiotics produced by a streptomycete. The producing strain was taxonomically studied and named Streptomyces griseus subsp. cryophilus. Cobaltous compounds were necessary for production of the antibiotics. C-19393 S2 and H2 showed a broad spectrum of antibacterial activities with C-19393 H2 being 8 approximately 120 times more active than C-19393 S2. They also exhibited beta-lactamase-inhibiting activities and acted synergistically with ampicillin and cefotiam against clinical isolates resistant to beta-lactam antibiotics.
C-19393 S2和H2是由链霉菌产生的新型碳青霉烯类抗生素。对产生菌株进行了分类学研究，并命名为嗜冷灰链霉菌亚种。钴化合物是抗生素生产所必需的。C-19393 S2和H2具有广谱抗菌活性，其中C-19393 H2的活性比C-19393 S2高约8至120倍。它们还表现出β-内酰胺酶抑制活性，并与氨苄西林和头孢替安协同作用，对抗对β-内酰胺类抗生素耐药的临床分离株。
