Butylated hydroxytoluene pretreatment protects against cytotoxicity and reduces covalent binding of aflatoxin B1 in primary hepatocyte cultures.

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作者信息

Salocks C B, Hsieh D P, Byard J L

出版信息

Toxicol Appl Pharmacol. 1981 Jun 30;59(2):331-45. doi: 10.1016/0041-008x(81)90205-2.

DOI:10.1016/0041-008x(81)90205-2

PMID:6789502

Abstract

摘要

相似文献

Butylated hydroxytoluene pretreatment protects against cytotoxicity and reduces covalent binding of aflatoxin B1 in primary hepatocyte cultures.

Toxicol Appl Pharmacol. 1981 Jun 30;59(2):331-45. doi: 10.1016/0041-008x(81)90205-2.

Effects of butylated hydroxytoluene pretreatment on the metabolism and genotoxicity of aflatoxin B1 in primary cultures of adult rat hepatocytes: selective reduction of nucleic acid binding.丁基羟基甲苯预处理对成年大鼠肝细胞原代培养物中黄曲霉毒素B1代谢及遗传毒性的影响：核酸结合的选择性降低

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The effects of butylated hydroxytoluene on the in vitro metabolism, DNA-binding and mutagenicity of aflatoxin B1 in the rat.丁基羟基甲苯对大鼠体外黄曲霉毒素B1代谢、DNA结合及致突变性的影响。

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Effect of butylated hydroxytoluene pretreatment on the excretion, tissue distribution and DNA binding of [14C]aflatoxin B1 in the rat.

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Modification of aflatoxin B1 binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquin and a dithiothione.在喂食酚类抗氧化剂、乙氧喹和二硫代硫酮的大鼠体内，黄曲霉毒素B1与DNA结合的修饰作用。

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Butylated hydroxytoluene chemoprevention of aflatoxicosis - effects on aflatoxin B(1) bioavailability, hepatic DNA adduct formation, and biliary excretion.丁基羟基甲苯对黄曲霉毒素中毒的化学预防作用——对黄曲霉毒素B(1)生物利用度、肝脏DNA加合物形成及胆汁排泄的影响

Food Chem Toxicol. 2008 Dec;46(12):3727-31. doi: 10.1016/j.fct.2008.09.050. Epub 2008 Sep 26.

Effect of butylated hydroxyanisole pretreatment on in vitro hepatic aflatoxin B1-DNA binding and aflatoxin B1-glutathione conjugation in rats.丁基羟基茴香醚预处理对大鼠体外肝脏黄曲霉毒素B1-DNA结合及黄曲霉毒素B1-谷胱甘肽结合的影响。

Cancer Res. 1988 May 15;48(10):2688-92.

Inhibition of aflatoxin B1-induced cytotoxicity and binding to DNA in cultured rat liver cells by naturally occurring flavones.

J Environ Pathol Toxicol. 1979 Mar-Apr;2(4):1021-8.

Effect of butylated hydroxytoluene on the disposition of [14C]aflatoxin B1 in the lactating rat.

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Modulation of aflatoxin metabolism, aflatoxin-N7-guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: role of induction of glutathione S-transferases.乙氧喹啉喂养大鼠中黄曲霉毒素代谢、黄曲霉毒素-N7-鸟嘌呤形成及肝脏肿瘤发生的调节：谷胱甘肽S-转移酶诱导的作用。

Cancer Res. 1986 Aug;46(8):3924-31.

引用本文的文献

An in vitro approach to the study of target organ toxicity of drugs and chemicals.一种研究药物和化学物质靶器官毒性的体外方法。

In Vitro Cell Dev Biol. 1985 Sep;21(9):495-504. doi: 10.1007/BF02620841.

Comparative metabolism and toxicity of chemical carcinogens in primary cultures of hepatocytes.原代肝细胞培养中化学致癌物的比较代谢与毒性

In Vitro Cell Dev Biol. 1985 Sep;21(9):489-94. doi: 10.1007/BF02620840.

Comparative uptake, vascular transport, and cellular internalization of aflatoxin-B1 and benzo(a)pyrene.黄曲霉毒素B1与苯并(a)芘的摄取、血管转运及细胞内化比较

Arch Toxicol. 1990;64(4):285-90. doi: 10.1007/BF01972988.

Neutral red (NR) assay for cell viability and xenobiotic-induced cytotoxicity in primary cultures of human and rat hepatocytes.用于检测人及大鼠原代肝细胞活力和外源性物质诱导细胞毒性的中性红（NR）检测法。

Cell Biol Toxicol. 1990 Apr;6(2):219-34. doi: 10.1007/BF00249595.

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