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肥胖儿童和青少年的催乳素分泌紊乱。

Disordered prolactin secretion in the obese child and adolescent.

作者信息

Cacciari E, Frejaville E, Balsamo A, Cicognani A, Pirazzoli P, Bernardi F, Zappulla F

出版信息

Arch Dis Child. 1981 May;56(5):386-9. doi: 10.1136/adc.56.5.386.

Abstract

Thirty-eight obese (13 prepubertal, 25 pubertal) boys, and 17 obese (16 prepubertal, 11 pubertal) girls underwent a thyroid-releasing hormone test with assay of prolactin. Obese pre-pubertal boys had prolactin levels that were significantly below those of the control group both under basal conditions and after stimulus. In the obese pubertal boys the difference was significant only after stimulus. The pituitary prolactin reserve in obese pubertal girls was lower than that of the control group. We conclude that in children and adolescents obesity may induce a hypothalamo-pituitary disorder that affects prolactin secretion.

摘要

38名肥胖男孩(13名青春期前,25名青春期)和17名肥胖女孩(16名青春期前,11名青春期)接受了促甲状腺激素释放激素测试并检测了催乳素。肥胖的青春期前男孩在基础状态和刺激后催乳素水平均显著低于对照组。肥胖的青春期男孩仅在刺激后差异显著。肥胖青春期女孩的垂体催乳素储备低于对照组。我们得出结论,在儿童和青少年中,肥胖可能诱发影响催乳素分泌的下丘脑 - 垂体疾病。

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Impaired hypothalamic control of prolactin secretion in massive obesity.
Lancet. 1979 Apr 7;1(8119):747-50. doi: 10.1016/s0140-6736(79)91206-6.

本文引用的文献

2
Radioimmunoassay of thyrotropin in human serum.人血清促甲状腺激素的放射免疫测定
J Clin Endocrinol Metab. 1965 Sep;25(9):1179-88. doi: 10.1210/jcem-25-9-1179.
3
Prolactin-related testosterone secretion in normal adult men.
J Clin Endocrinol Metab. 1976 Jan;42(1):112-6. doi: 10.1210/jcem-42-1-112.
4
Serum prolactin levels during puberty.青春期的血清催乳素水平。
Am J Obstet Gynecol. 1975 Apr 1;121(7):995-7. doi: 10.1016/0002-9378(75)90925-4.
7
Serum prolactin, FSH and LH during puberty in girls and boys.
Acta Paediatr Scand. 1978 Jul;67(4):417-23. doi: 10.1111/j.1651-2227.1978.tb16348.x.
10
Impaired hypothalamic control of prolactin secretion in massive obesity.
Lancet. 1979 Apr 7;1(8119):747-50. doi: 10.1016/s0140-6736(79)91206-6.

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