Kurosumi K, Inoue K
Arch Histol Jpn. 1980 Oct;43(4):373-82. doi: 10.1679/aohc1950.43.373.
For a long time, the occurrence of exocytotic discharge of secretory granules from the typical gonadotrophs (Type 1 gonadotrophs) of the anterior pituitary has been doubted. A simple observation with immunocytochemistry and morphometric examination using transmission electron microscopes indicated an increase in number of surface pits and subsurface vesicles of the typical gonadotrophs after castration, which were confirmed by immunocytochemical reaction with anti-LH beta. Large pits and vesicles were also increased progressively as days after castration advanced. Some large pits contained dense granules or less dense flocculent substance. These findings suggest that the typical gonadotrophs also exert granule discharge by the mechanism of exocytosis and concomitant retrieval of surface plasma membrane by the micropinocytosis.
长期以来，垂体前叶典型促性腺激素细胞（1型促性腺激素细胞）分泌颗粒的胞吐释放现象一直受到质疑。一项使用透射电子显微镜进行免疫细胞化学和形态计量学检查的简单观察表明，去势后典型促性腺激素细胞的表面凹陷和亚表面囊泡数量增加，这通过抗促黄体生成素β亚基的免疫细胞化学反应得到证实。随着去势后天数的增加，大的凹陷和囊泡也逐渐增多。一些大的凹陷含有致密颗粒或密度较低的絮状物质。这些发现表明，典型促性腺激素细胞也通过胞吐机制以及伴随的微胞饮作用回收表面质膜来进行颗粒释放。
