Isidori A, Lo Monaco A, Cappa M
Curr Med Res Opin. 1981;7(7):475-81. doi: 10.1185/03007998109114287.
A study was carried out in 15 male volunteers to evaluate qualitatively the secretion of growth factors following stimulation by oral amino acids. The results showed that oral administration of a combination of two amino acids (1200 mg 1-lysine plus 1200 mg 1-arginine) provoked a release of pituitary somatotropin and insulin. This phenomenon was reproducible and the growth hormone secreted in response to this stimulation had biological activity (as demonstrated by a radioreceptor assay and somatomedin induction). The effect appeared to be specific to the combination of the two amino acids; neither of the amino acids demonstrated appreciable stimulating activity when administered alone, even at the same doses.
一项针对15名男性志愿者的研究开展，以定性评估口服氨基酸刺激后生长因子的分泌情况。结果显示，口服两种氨基酸的组合（1200毫克L-赖氨酸加1200毫克L-精氨酸）会引发垂体生长激素和胰岛素的释放。这种现象具有可重复性，并且对这种刺激产生反应而分泌的生长激素具有生物活性（通过放射受体测定和生长调节素诱导证明）。这种效应似乎对这两种氨基酸的组合具有特异性；单独给予这两种氨基酸中的任何一种时，即使剂量相同，也未显示出明显的刺激活性。
