对黑腹果蝇α-甘油磷酸脱氢酶基因座周围染色体区域的细胞遗传学分析。
A cytogenetic analysis of the chromosomal region surrounding the alpha-glycerophosphate dehydrogenase locus of Drosophila melanogaster.
作者信息
Kotarski M A, Pickert S, MacIntyre R J
出版信息
Genetics. 1983 Oct;105(2):371-86. doi: 10.1093/genetics/105.2.371.
Abstract
The chromosomal region surrounding the structural gene for alpha-glycerophosphate dehydrogenase (alpha Gpdh, 2-20.5) of Drosophila melanogaster has been studied in detail. Forty-three EMS-induced recessive lethal mutations and five previously identified visible mutations have been localized within the 25A-27D region of chromosome 2 by deficiency mapping and in some cases by a recombination analysis. The 43 lethal mutations specify 17 lethal loci. alpha Gpdh has been localized to a single polytene chromosome band, 25F5, and there apparently are no lethals that map to the alpha Gpdh locus.
摘要
对黑腹果蝇α-甘油磷酸脱氢酶（αGpdh，2 - 20.5）结构基因周围的染色体区域进行了详细研究。通过缺失定位，并在某些情况下通过重组分析，已将43个经EMS诱导的隐性致死突变和5个先前鉴定的可见突变定位在2号染色体的25A - 27D区域内。这43个致死突变确定了17个致死位点。αGpdh已定位到一条单一的多线染色体带，即25F5，显然没有致死突变定位于αGpdh基因座。
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