人卵巢肿瘤对化疗药物的体外敏感性
In vitro sensitivity of human ovarian tumours to chemotherapeutic agents.
作者信息
Wilson A P, Neal F E
出版信息
Br J Cancer. 1981 Aug;44(2):189-200. doi: 10.1038/bjc.1981.170.
Abstract
The in vitro chemosensitivity of primary monolayer cultures of human ovarian tumours to a wide range of chemotherapeutic agents has been determined using 3H-leucine incorporation as an index of cytotoxicity. Of 67 specimens received, 35 have been successfully cultured and tested for chemosensitivity. Drugs tested included alkylating agents, antibiotics, antimitotics, antimetabolites and progestogens. The overall incidence of efficacy of the drugs corresponded with the incidence which might be expected from data on the clinical response rates produced by the various drugs. Cultures from the tumour cells of treated patients generally showed greater resistance than tumours of untreated patients. Correlation between in vitro results and in vivo response was positive in all 8 patients receiving first-line chemotherapy and in 57% (4/7) patients receiving second-line chemotherapy.
摘要
利用³H-亮氨酸掺入作为细胞毒性指标，已测定了人卵巢肿瘤原代单层培养物对多种化疗药物的体外化学敏感性。在收到的67个标本中，35个已成功培养并进行了化学敏感性测试。所测试的药物包括烷化剂、抗生素、抗有丝分裂剂、抗代谢物和孕激素。药物疗效的总体发生率与根据各种药物产生的临床反应率数据所预期的发生率相符。来自接受治疗患者肿瘤细胞的培养物通常比未治疗患者的肿瘤表现出更大的耐药性。在所有8例接受一线化疗的患者以及57%（4/7）接受二线化疗的患者中，体外结果与体内反应之间呈正相关。
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