医院患者中庆大霉素耐药肠杆菌科细菌耐药质粒的传播
Dissemination of resistance plasmids among gentamicin-resistant enterobacteria from hospital patients.
作者信息
Knight S, Casewell M
出版信息
Br Med J (Clin Res Ed). 1981 Sep 19;283(6294):755-6. doi: 10.1136/bmj.283.6294.755.
Abstract
Out of 184 patients who were infected or colonised with gentamicin-resistant enterobacteria, 17 (9%) harboured more than one strain. Single antibiotic-resistance plasmids were common to more than one of the different organisms isolated from nine patients, strongly suggestive of in-vivo conjugation. An "epidemic" plasmid with a molecular weight of approximately 110 megadaltons was found in 11 distinct strains isolated from four patients. Seven of the organisms harbouring this plasmid were Klebsiella aerogenes. Spread of multiple-resistance plasmids among endemic gentamicin-resistant enterobacteria is not uncommon, and these organisms provide a reservoir of plasmids that may ultimately spread to more pathogenic genera.
摘要
在184例感染或定植有耐庆大霉素肠杆菌的患者中，17例（9%）携带不止一种菌株。单一抗生素耐药质粒在从9例患者分离出的不止一种不同微生物中常见，强烈提示体内接合作用。在从4例患者分离出的11种不同菌株中发现了一种分子量约为110兆道尔顿的“流行”质粒。携带这种质粒的7种微生物为产气克雷伯菌。多重耐药质粒在地方性耐庆大霉素肠杆菌中传播并不罕见，这些微生物提供了一个质粒库，最终可能传播到更具致病性的菌属。
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