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[129/J小鼠细胞中C型内源性病毒的化学激活缺失]

[Absence of the chemical activation of type C endogenous viruses in cells of 129/J mice].

作者信息

Escot C, Tobaly J, Robert-Lezenes J, Peries J, Emanoil-Ravicovitch R

出版信息

C R Seances Acad Sci III. 1981 May 11;292(17):995-8.

PMID:6791775
Abstract

Production of Type C virus by Mouse cells generally activated by chemical agents does not occur in 129/J Mouse cells. No viral production, as tested by reverse transcriptase activity and electron microscopic methods can be detected in cells treated by chemical inducers. Immunofluorescence does not reveal the presence of viral specific proteins and viral RNA expression determined by molecular hybridization between cellular RNA and viral cDNA does not increase as it does in BALB/c cells under the action of the inducers studied.

摘要

通常由化学试剂激活的小鼠细胞产生C型病毒的情况在129/J小鼠细胞中不会发生。在用化学诱导剂处理的细胞中,通过逆转录酶活性和电子显微镜方法检测,未发现病毒产生。免疫荧光未显示病毒特异性蛋白的存在,并且通过细胞RNA与病毒cDNA之间的分子杂交确定的病毒RNA表达,在研究的诱导剂作用下,不像在BALB/c细胞中那样增加。

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