Pirisino R, Mangano G, Ceppatelli P, Corrias M, Ignesti G, Carla V, Vettori L P
Farmaco Sci. 1981 Aug;36(8):682-91.
The paper reports the inhibitory activity (ID50) of a series of 2-phenylpyrazolo [1,5-a]pyrimidines on prostaglandin synthetase of guinea-pig lung homogenate in comparison with indomethacin. In vivo studies showed that some of these compounds possess interesting antiinflammatory, antipyretic and analgesic properties, as compared to those of classic non steroid antiinflammatory drugs like aspirin or phenylbutazone.
