Kim S H, Kim J H, Hahn E W
Cancer Res. 1978 Sep;38(9):2935-8.
The modification of cell lethality at elevated temperatures by 5-thio-D-glucose, the nearest analog of D-glucose was studied with the use of HeLa cells in the presence or absence of oxygen. When the cells were exposed to temperatures ranging from 40.5-42 degrees for 0.5 to 4 hr in the presence of 5-thio-D-glucose (5 mM), there was a selective potentiation of hyperthermic killing of hypoxic cells. No enhanced killing of oxic cells by 5-thio-D-glucose was seen at these temperatures. These results indicate that glucose metabolism may be involved in influencing the heat sensitivity of hypoxic cells. The low toxicity of 5-thio-D-glucose and its specificity to hypoxic cells suggest that it may be a useful adjuvant to hyperthermic therapy.
在有氧或无氧条件下，使用HeLa细胞研究了5-硫代-D-葡萄糖（D-葡萄糖的最接近类似物）对高温下细胞杀伤力的影响。当细胞在5-硫代-D-葡萄糖（5 mM）存在的情况下暴露于40.5-42摄氏度的温度0.5至4小时时，缺氧细胞的热杀伤作用有选择性增强。在这些温度下，未观察到5-硫代-D-葡萄糖对有氧细胞的杀伤作用增强。这些结果表明，葡萄糖代谢可能参与影响缺氧细胞的热敏感性。5-硫代-D-葡萄糖的低毒性及其对缺氧细胞的特异性表明，它可能是热疗的有用佐剂。
