Casslén B, Rosengren M, Ohlsson K
Hoppe Seylers Z Physiol Chem. 1981 Jul;362(7):953-61. doi: 10.1515/bchm2.1981.362.2.953.
Antileukoprotease was demonstrated in the cervical mucosa, but was absent in the endometrium. It was shown immunohistologically to predominate in the epithelial lining of the cervical crypts. High concentrations were found in the cervical mucus. Although antileukoprotease was not present in the endometrium, low concentrations were found in the uterine fluid, probably secondary to diffusion from the cervical mucus. The concentration of antileukoprotease in cervical mucus varied greatly during the menstrual cycle, but no midcycle minimum was found. Increased concentrations were found in samples obtained during the week preceding onset of the menstruation in most women. Antileukoprotease was present in uterine fluid from intra uterine device (IUD) non-users in its free form. In fluid from IUD users it was partly in its free form, and partly in a complexed form. The major part of the non-complexed portion was biologically active. The complex consisted, at least partly, of elastase bound to antileukoprotease. Antileukoprotease may thus contribute to the neutralization of granulocyte elastase in the uterine fluid of IUD users.
抗白细胞蛋白酶在宫颈黏膜中被证实存在，但在子宫内膜中不存在。免疫组织化学显示其在宫颈隐窝的上皮衬里中占主导。在宫颈黏液中发现高浓度。虽然子宫内膜中不存在抗白细胞蛋白酶，但在子宫液中发现低浓度，这可能是宫颈黏液扩散所致。宫颈黏液中抗白细胞蛋白酶的浓度在月经周期中变化很大，但未发现周期中期最低值。在大多数女性月经开始前一周采集的样本中发现浓度增加。抗白细胞蛋白酶以游离形式存在于未使用宫内节育器（IUD）女性的子宫液中。在使用IUD女性的子宫液中，它部分以游离形式存在，部分以复合形式存在。非复合部分的主要部分具有生物活性。该复合物至少部分由与抗白细胞蛋白酶结合的弹性蛋白酶组成。因此，抗白细胞蛋白酶可能有助于中和使用IUD女性子宫液中的粒细胞弹性蛋白酶。
