Schläppy P, Paunier L, Cuendet A
Helv Paediatr Acta. 1981 Jul;36(3):241-8.
The efficacy of a long-term prophylaxis with Co-trimoxazole was studied in 18 girls with recurrent urinary tract infections. SEven patients had neither anatomical nor functional anomalies of the urinary tract. Eight patients had a vesico-ureteral reflux, and three patients a complex urinary problem. The following therapeutic plan was applied: administration of a low dose of Co-trimoxazole (TMP: 0,6-1 mg/kg) given as a single evening dose during 3 months followed by a 3-month period without treatment. The children were followed in this way during 2 years. Seven children had no reinfection from the start of the prophylaxis during the 2 years of observation. Nine children had a significant decrease of the number of reinfections during the Co-trimoxazole treatment periods. Two children without anatomical anomaly had early reinfections with Co-trimoxazole resistant germs. No side effects related to Co-trimoxazole have been observed, and the tolerance of treatment was excellent. Co-trimoxazole administered as a single evening low dose efficiently prevented the recurrence of urinary tract infections.
对18名复发性尿路感染女童进行了复方新诺明长期预防效果的研究。7名患者尿路既无解剖学异常也无功能异常。8名患者存在膀胱输尿管反流，3名患者存在复杂的泌尿问题。采用了以下治疗方案：给予低剂量复方新诺明（甲氧苄啶：0.6 - 1毫克/千克），于每晚单次给药，持续3个月，随后3个月不进行治疗。以这种方式对儿童进行了2年的随访。在2年观察期内，7名儿童自预防开始就没有再次感染。9名儿童在复方新诺明治疗期间再次感染的次数显著减少。2名无解剖学异常的儿童早期出现了对复方新诺明耐药菌的再次感染。未观察到与复方新诺明相关的副作用，治疗耐受性良好。每晚单次给予低剂量复方新诺明可有效预防尿路感染复发。
