Jones R H
J R Coll Gen Pract. 1983 Sep;33(254):585-9.
One hundred and sixteen adults with symptoms of acute urinary tract infection were randomly collected into four groups and given single-dose or seven-day treatment with trimethoprim or co-trimoxazole. Of the 105 patients who completed the study, bacterial urinary infection was present in 70 patients (67 per cent). The rates for symptomatic and bacterial cures were high and indistinguishable between the groups, and there was no difference in the rate of recurrence of urinary infection in the six weeks after treatment. Side effects were lower in the group receiving single-dose trimethoprim (P=0.09).
116名有急性尿路感染症状的成年人被随机分为四组，接受甲氧苄啶或复方新诺明单剂量或为期七天的治疗。在完成研究的105名患者中，70名患者（67%）存在细菌性尿路感染。症状缓解率和细菌清除率都很高，且各组之间无明显差异，治疗后六周内尿路感染复发率也无差异。接受单剂量甲氧苄啶治疗的组副作用较少（P=0.09）。
