Perlman K L, Schömer U, Williams T H, Perlman D
J Antibiot (Tokyo). 1981 May;34(5):483-8. doi: 10.7164/antibiotics.34.483.
4-Keto-5-amino-6-hydroxyhexanoic acid was isolated from Bacillus cereus 102804 fermentations and found to inhibit the growth of Gram-positive and Gram-negative bacteria, when grown in a chemically defined medium. The mechanism appeared to be the inhibition of delta-aminolevulinic acid dehydratase. The Ki value of 4-keto-5-amino-6-hydroxyhexanoic acid in an enzyme preparation of Propionibacterium shermanii was 0.72 microM. Similar test conditions with 4-keto-5-aminohexanoic acid resulted in Ki of 12.1 microM. In both cases competitive inhibition was found. The structure of 4-keto-5-amino-6-hydroxyhexanoic acid was determined.
从蜡样芽孢杆菌102804发酵产物中分离出4-酮基-5-氨基-6-羟基己酸，发现在化学限定培养基中生长时，它能抑制革兰氏阳性菌和革兰氏阴性菌的生长。其作用机制似乎是抑制δ-氨基乙酰丙酸脱水酶。4-酮基-5-氨基-6-羟基己酸在谢氏丙酸杆菌酶制剂中的Ki值为0.72微摩尔。在相似测试条件下，4-酮基-5-氨基己酸的Ki值为12.1微摩尔。在这两种情况下均发现存在竞争性抑制作用。已确定了4-酮基-5-氨基-6-羟基己酸的结构。
