钝顶螺旋藻抗类似物突变体生产氨基酸
Production of amino acids by analog-resistant mutants of the cyanobacterium Spirulina platensis.
作者信息
Riccardi G, Sora S, Ciferri O
出版信息
J Bacteriol. 1981 Sep;147(3):1002-7. doi: 10.1128/jb.147.3.1002-1007.1981.
Abstract
Mutants of Spirulina platensis resistant to 5-fluorotryptophan, beta-3-thienyl-alanine, ethionine, p-fluorophenylalanine, or azetidine-2-carboxylic acid were isolated. Some of these mutants appeared to be resistant to more than one analog and to overproduce the corresponding amino acids. A second group was composed of mutants that were resistant to one analog only. Of the latter mutants, one resistant to azetidine-2-carboxylic acid was found to overproduce proline only, whereas one resistant to fluorotryptophan and one resistant to ethionine did not overproduce any of the tested amino acids.
摘要
分离出了对5-氟色氨酸、β-3-噻吩丙氨酸、乙硫氨酸、对氟苯丙氨酸或氮杂环丁烷-2-羧酸具有抗性的钝顶螺旋藻突变体。其中一些突变体似乎对不止一种类似物具有抗性，并过量产生相应的氨基酸。第二组由仅对一种类似物具有抗性的突变体组成。在后者这些突变体中，发现一个对氮杂环丁烷-2-羧酸具有抗性的突变体仅过量产生脯氨酸，而一个对氟色氨酸具有抗性的突变体和一个对乙硫氨酸具有抗性的突变体并未过量产生任何测试的氨基酸。
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