Sklar L S, Bruto V, Anisman H
Psychosom Med. 1981 Aug;43(4):331-42. doi: 10.1097/00006842-198108000-00006.
Growth of P815 mastocytoma in syngeneic DBA/2J male mice was evaluated following several stress regimens. Although escapable shock did not enhance tumor growth, an equivalent amount of inescapable shock applied in a yoked paradigm markedly augmented tumor development. If mice received repeated stress sessions on 5-10 consecutive following tumor cell transplantation, the tumor-enhancing effects of an acute session were abrogated. This effect was not due to an antitumor effect exerted by a shock session applied several days after cell transplantation. It seems that the tumorigenic effects of stress are subject to adaptation since stress exposure prior to cell transplantation also inhibited the effects of an acute stress session. The data were discussed in relation to stress-induced neurochemical alterations.
在几种应激方案后，评估了同基因DBA/2J雄性小鼠中P815肥大细胞瘤的生长情况。虽然可逃避的电击并未促进肿瘤生长，但在配对模式下施加等量的不可逃避电击显著增强了肿瘤发展。如果小鼠在肿瘤细胞移植后的5至10天连续接受重复应激，急性应激的肿瘤增强作用就会被消除。这种效应并非由于细胞移植几天后施加的电击产生的抗肿瘤作用。应激的致瘤作用似乎会产生适应性，因为细胞移植前的应激暴露也抑制了急性应激的作用。结合应激诱导的神经化学变化对这些数据进行了讨论。
