多种生物碱对人类精子代谢及运动能力的抑制作用。

Inhibition of the metabolism and motility of human spermatozoa by various alkaloids.

作者信息

Trifunac N P, Berstein G S

出版信息

Contraception. 1982 Jan;25(1):69-87. doi: 10.1016/0010-7824(82)90020-8.

Abstract

The ability of several alkaloids to inhibit the metabolism and motility of human spermatozoa has been investigated. Of the agents tested, chloroquine was the most effective in inhibiting sperm metabolism (production of carbon dioxide and lactic acid) and motility. It was active at a concentration of 3.6 x 10(-5)M. Quinine and Quinacrine were active at concentrations of 5 x 10(-4)M and emetine required concentrations as high as 3.6 x 10(-3)M to achieve an inhibitory effect. Detailed studies with emetine showed that the time needed for inhibition of sperm motility was inversely proportional to the drug concentration and directly related to the sperm density. In addition, the inhibition was shown not to be reversible.

摘要

已对多种生物碱抑制人类精子代谢和运动能力进行了研究。在所测试的药物中，氯喹在抑制精子代谢（二氧化碳和乳酸生成）和运动方面最为有效。其在3.6×10⁻⁵M的浓度下具有活性。奎宁和阿的平在5×10⁻⁴M的浓度下具有活性，而依米丁需要高达3.6×10⁻³M的浓度才能产生抑制作用。对依米丁的详细研究表明，抑制精子运动所需的时间与药物浓度成反比，与精子密度成正比。此外，这种抑制作用不可逆。