Amir S
Center for Neurosciences and Behavioral Research, Weizmann Institute of Science, Israel.
Brain Res. 1988 Feb 2;440(1):181-4. doi: 10.1016/0006-8993(88)91174-2.
The influence of aging on the thermoregulatory effect of thyrotropin-releasing hormone (TRH) was studied in young (3-month-old) and aged (24-month-old) chloral hydrate-treated rats subjected either to normothermic (23 degrees C) or cold (4 degrees C) environment. Cerebroventricular injection of TRH (1 or 10 micrograms) or the TRH analog, CG 3509 (0.1 or 1 microgram), significantly enhanced the decline of body temperature in the young, anaesthetized rats, both in the normal and cold environments, but had no effect whatsoever on the decrease in body temperature in the chloral hydrate-treated aged animals. These results suggest that aging impairs the central mechanism(s) involved in the thermoregulatory action of TRH.
在水合氯醛处理的年轻（3个月大）和老年（24个月大）大鼠中，研究了衰老对促甲状腺激素释放激素（TRH）体温调节作用的影响，这些大鼠分别处于常温（23摄氏度）或寒冷（4摄氏度）环境。脑室注射TRH（1或10微克）或TRH类似物CG 3509（0.1或1微克），在正常和寒冷环境中，均能显著增强年轻麻醉大鼠的体温下降，但对水合氯醛处理的老年动物的体温下降没有任何影响。这些结果表明，衰老损害了参与TRH体温调节作用的中枢机制。
