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与格列本脲治疗相关的肝内胆汁淤积和皮肤大疱

Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy.

作者信息

Wongpaitoon V, Mills P R, Russell R I, Patrick R S

出版信息

Postgrad Med J. 1981 Apr;57(666):244-6. doi: 10.1136/pgmj.57.666.244.

Abstract

Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented wit hypoglycaemic coma. These features have not previously been reported as side effects of glibenclamide therapy, but intrahepatic cholestasis may occur with chlorpropamide, a similar sulphonylurea agent. The mechanism of this cholestasis is not clear at present.

摘要

一名61岁的糖尿病患者出现低血糖昏迷,其在接受格列本脲治疗时出现了肝内胆汁淤积和皮肤大疱。这些特征此前未被报道为格列本脲治疗的副作用,但肝内胆汁淤积可能发生在氯磺丙脲(一种类似的磺酰脲类药物)治疗时。目前这种胆汁淤积的机制尚不清楚。

相似文献

6
[Hypoglycemic coma caused by glibenclamide].
Rev Clin Esp. 1971 Mar 15;120(5):481-4.
7
Glibenclamide-induced cholestasis.格列本脲诱导的胆汁淤积。
J Hepatol. 1991 Nov;13(3):375. doi: 10.1016/0168-8278(91)90085-p.

本文引用的文献

3
[A new highly-active oral antidiabetic].
Arzneimittelforschung. 1966 Dec;16(12):1640-1.
7
Anaphylactic reaction to chlorpropamide.对氯磺丙脲的过敏反应。
Br Med J. 1971 Jul 17;3(5767):162. doi: 10.1136/bmj.3.5767.162.
8
Chlorpropamide hyponatremia: drug-induced inappropriate antidiuretic-hormone activity.
N Engl J Med. 1971 Jan 14;284(2):65-71. doi: 10.1056/NEJM197101142840202.
9
Adverse reactions to oral antidiabetic agents.口服抗糖尿病药物的不良反应。
Br Med J. 1971 Jul 3;3(5765):29-30. doi: 10.1136/bmj.3.5765.29.

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