Wongpaitoon V, Mills P R, Russell R I, Patrick R S
Postgrad Med J. 1981 Apr;57(666):244-6. doi: 10.1136/pgmj.57.666.244.
Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented wit hypoglycaemic coma. These features have not previously been reported as side effects of glibenclamide therapy, but intrahepatic cholestasis may occur with chlorpropamide, a similar sulphonylurea agent. The mechanism of this cholestasis is not clear at present.
一名61岁的糖尿病患者出现低血糖昏迷,其在接受格列本脲治疗时出现了肝内胆汁淤积和皮肤大疱。这些特征此前未被报道为格列本脲治疗的副作用,但肝内胆汁淤积可能发生在氯磺丙脲(一种类似的磺酰脲类药物)治疗时。目前这种胆汁淤积的机制尚不清楚。