老年人血压降低：甲基多巴的一项随机对照试验
Blood pressure reduction in elderly: a randomised controlled trial of methyldopa.
作者信息
Sprackling M E, Mitchell J R, Short A H, Watt G
出版信息
Br Med J (Clin Res Ed). 1981 Oct 31;283(6300):1151-3. doi: 10.1136/bmj.283.6300.1151.
Abstract
A total of 123 out of 549 elderly residents of local authority welfare homes in Nottinghamshire were found at screening to have a standing or lying diastolic blood pressure of 100 mm Hg or more. These 123 subjects were randomly allocated to simple observation or to treatment with methyldopa. The cumulative mortality was similar in the observed and treated groups and in the normotensive group from which the subjects had been separated. Thus moderate hypertension, whether treated or not, was not a major risk predictor in the elderly population studied.
摘要
在诺丁汉郡地方政府福利院的549名老年居民中，共有123人在筛查时被发现站立或卧位舒张压为100毫米汞柱或更高。这123名受试者被随机分配至单纯观察组或接受甲基多巴治疗组。观察组、治疗组以及从中分离出这些受试者的血压正常组的累积死亡率相似。因此，在本研究的老年人群中，中度高血压无论是否接受治疗，都不是主要的风险预测因素。
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