良性前列腺增生患者中3H-睾酮和3H-双氢睾酮的代谢动力学。醋酸环丙孕酮的作用。
Kinetics of 3H-testosterone and 3H-dihydrotestosterone metabolism in patients with benign prostatic hypertrophy. Effect of cyproterone acetate.
作者信息
Hutschenreiter G, Sinterhauf K, Altwein J E
出版信息
Eur Urol. 1977;3(2):100-4. doi: 10.1159/000472068.
The response of 3H-testosterone and 3H-dihydrotestosterone to the administration of cyproterone acetate (CA) over a period of 5 days was investigated. Both tracers were injected intravenously in patients with benign prostatic hypertrophy. Blood was withdrawn for up to 5 h. Benign prostatic hypertrophy tissue was obtained by transurethral resection. Nine patients served as controls. Eleven patients received 300 mg CA intramuscularly. Cyproterone acetate suppressed testosterone and FSH, but not LH. 3H-testosterone was cleared more rapidly from plasma in the patients given CA presumably due to increased metabolism in the liver. 3H-dihydrotestosterone, however, remained virtually uninfluenced. Moreover, CA did not significantly alter the 3H-testosterone and 3H-dihydrotestosterone uptake and metabolism within prostatic tissue.
研究了在5天时间内，醋酸环丙孕酮（CA）给药后3H-睾酮和3H-双氢睾酮的反应。两种示踪剂均静脉注射给良性前列腺增生患者。采血长达5小时。通过经尿道切除术获取良性前列腺增生组织。9名患者作为对照。11名患者接受了300毫克CA肌肉注射。醋酸环丙孕酮抑制了睾酮和促卵泡激素，但不抑制促黄体生成素。给予CA的患者血浆中3H-睾酮清除更快，可能是由于肝脏代谢增加。然而，3H-双氢睾酮几乎未受影响。此外，CA并未显著改变前列腺组织内3H-睾酮和3H-双氢睾酮的摄取及代谢。
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