Mazureka C, Stiffel C, Chalvet H, Biozzi G
C R Seances Acad Sci III. 1981 Oct 5;293(4):225-8.
The antitumor properties of Corynebacterium parvum have been studied in Mice of different ages of two inbred strains: XVII Mice and C3H Mice grafted with syngeneic tumors. The antitumor protection was very weak in young Mice: no effect on mortality rate, only an increase in mean survival time was observed. The highest level of protection was obtained in 2-5 month old Mice (100% of survival) In aged Mice this antitumor protection decreases more rapidly in C3H Mice than in XVII Mice. It is interesting to note that 21 day old XVII Mice and 25 day old C3H Mice, non weaned, are partially protected by C. parvum (50% survival), while treated Mice of the same age, already weaned, are not.
已在两个近交系不同年龄的小鼠（XVII系小鼠和接种同基因肿瘤的C3H系小鼠）中研究了短小棒状杆菌的抗肿瘤特性。在幼龄小鼠中，抗肿瘤保护作用非常微弱：对死亡率没有影响，仅观察到平均存活时间有所增加。在2至5月龄的小鼠中获得了最高水平的保护（100%存活）。在老龄小鼠中，C3H系小鼠的这种抗肿瘤保护作用比XVII系小鼠下降得更快。值得注意的是，21日龄未断奶的XVII系小鼠和25日龄未断奶的C3H系小鼠受到短小棒状杆菌的部分保护（50%存活），而相同年龄已断奶的经处理小鼠则没有受到保护。
