Stiffel C, Chalvet H, Mazurek C
Ann Inst Pasteur Immunol (1985). 1985 Jul-Aug;136D(1):19-27.
The anti-tumor activity of Corynebacterium parvum against two different tumours, a mammary carcinoma grafted in C3H mice and a lymphosarcoma grafted in XVII mice, was lower in young and old mice, than in adult ones. In young mice (25 days) of both lines, low doses of C. parvum were more efficient than higher doses. In 12-month old XVII mice a higher survival rate was obtained by increasing the dose of C. parvum administered, whereas in old C3H mice, this phenomenon was not observed. Sublethal doses of X-irradiation abrogated the C. parvum-induced protection. Restoration of the protective effect occurred faster in 3-month old mice than in 8-month old mice. This restoration appeared earlier in XVII mice than in C3H mice.
短小棒状杆菌对两种不同肿瘤（接种于C3H小鼠的乳腺癌和接种于XVII小鼠的淋巴肉瘤）的抗肿瘤活性，在幼龄和老龄小鼠中比在成年小鼠中更低。在两个品系的幼龄小鼠（25日龄）中，低剂量的短小棒状杆菌比高剂量更有效。在12月龄的XVII小鼠中，通过增加短小棒状杆菌的给药剂量可获得更高的存活率，而在老龄C3H小鼠中未观察到这种现象。亚致死剂量的X射线照射消除了短小棒状杆菌诱导的保护作用。3月龄小鼠的保护作用恢复比8月龄小鼠更快。这种恢复在XVII小鼠中比在C3H小鼠中出现得更早。
