α-二氟甲基鸟氨酸作为雌性大鼠性交后有效的抗生育剂。

Alpha-difluoromethylornithine as a postcoitally effective antifertility agent in female rats.

作者信息

Reddy P R, Rukmini V

出版信息

Contraception. 1981 Aug;24(2):215-21. doi: 10.1016/0010-7824(81)90094-9.

Abstract

Intraperitoneal injection of alpha-difluoromethylornithine (DFMO) at a dose of 200 mg/kg, twice a day, during days 4-7 of pregnancy caused inhibition of embryogenesis in rats. These animals did not deliver any pups at term. However, there was no effect of DFMO on pregnant rats following treatment during day 1-3 of pregnancy. It was observed that DFMO completely abolished ornithine decarboxylase levels in the pregnant uterus. The action of DFMO appears to be due to the inhibition of putrescine and polyamines during a critical period of early embryo development. We suggest that this drug may act as a postcoitally effective antifertility agent in females.

摘要

在怀孕第4至7天，每天两次腹腔注射剂量为200毫克/千克的α-二氟甲基鸟氨酸（DFMO）可导致大鼠胚胎发育受到抑制。这些动物足月时未产下任何幼崽。然而，在怀孕第1至3天进行治疗后，DFMO对怀孕大鼠没有影响。据观察，DFMO可使怀孕子宫中的鸟氨酸脱羧酶水平完全消失。DFMO的作用似乎是由于在早期胚胎发育的关键时期抑制了腐胺和多胺。我们认为这种药物可能作为女性性交后有效的抗生育剂。