黑腹果蝇的第三染色体诱变敏感突变体。
Third-chromosome mutagen-sensitive mutants of Drosophila melanogaster.
作者信息
Boyd J B, Golino M D, Shaw K E, Osgood C J, Green M M
出版信息
Genetics. 1981 Mar-Apr;97(3-4):607-23. doi: 10.1093/genetics/97.3-4.607.
Abstract
A total of 34 third chromosomes of Drosophila melanogaster that render homozygous larvae hypersensitive to killing by chemical mutagens have been isolated. Genetic analyses have placed responsible mutations in more than eleven complementation groups. Mutants in three complementation groups are strongly sensitive to methyl methanesulfonate, those in one are sensitive to nitrogen mustard, and mutants in six groups are hypersensitive to both mutagens. Eight of the ten loci mapped fall within 15% of the genetic map that encompasses the centromere of chromosome 3. Mutants from four of the complementation groups are associated with moderate to strong meiotic effects in females. Preliminary biochemical analyses have implicated seven of these loci in DNA metabolism.
摘要
总共分离出34条黑腹果蝇的三号染色体，这些染色体使得纯合幼虫对化学诱变剂的杀伤作用高度敏感。遗传分析已将相关突变定位到十一个以上的互补群中。三个互补群中的突变体对甲磺酸甲酯高度敏感，一个互补群中的突变体对氮芥敏感，六个互补群中的突变体对这两种诱变剂都高度敏感。定位的十个基因座中有八个位于包含三号染色体着丝粒的遗传图谱的15%范围内。四个互补群中的突变体与雌性果蝇中度至强烈的减数分裂效应有关。初步生化分析表明，这些基因座中有七个与DNA代谢有关。
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本文引用的文献
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Chromosoma. 1981;82(2):249-57. doi: 10.1007/BF00286109.
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Effects of recombination-deficient and repair-deficient loci on meiotic and mitotic chromosome behavior in Drosophila melanogaster.重组缺陷和修复缺陷基因座对黑腹果蝇减数分裂和有丝分裂染色体行为的影响。
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Biochemical characterization of repair-deficient mutants of Drosophila.果蝇修复缺陷型突变体的生化特性
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