Cotner T, Blaser K, Kriedberg J, Potter M, Eisen H N
J Immunol. 1981 Nov;127(5):2150-5.
Serum and ascites fluid from mice bearing 260 different myeloma tumors were screened serologically for myeloma proteins having light chains like that of L315, the lambda 2 chain produced by myeloma MOPC-315. Four proteins, made by myelomas TEPC-952, CBPC-49, ABPC-72, and SAPC-15, were identified. Their light chains were essentially indistinguishable serologically from L315, and each of them also yielded the characteristic C-terminal amino acid (leucine) and C-terminal tryptic peptide of L315. However, amino acid sequences and other findings reported elsewhere have revealed that although the light chain of TEPC-952 is indeed a lambda 2 chain, the light chains of the others (CBPC-49, ABPC-72, and SAPC-15) represent another, slightly different type of light chain, which has been designated lambda 3.
对携带260种不同骨髓瘤肿瘤的小鼠的血清和腹水进行血清学筛查，以寻找具有与L315轻链相似的骨髓瘤蛋白，L315轻链是骨髓瘤MOPC - 315产生的λ2链。鉴定出了由骨髓瘤TEPC - 952、CBPC - 49、ABPC - 72和SAPC - 15产生的四种蛋白。它们的轻链在血清学上与L315基本无法区分，并且它们各自还产生了L315特有的C端氨基酸（亮氨酸）和C端胰蛋白酶肽。然而，其他地方报道的氨基酸序列和其他发现表明，虽然TEPC - 952的轻链确实是λ2链，但其他几种（CBPC - 49、ABPC - 72和SAPC - 15）的轻链代表了另一种略有不同的轻链类型，已被命名为λ3。
