用针对Ia决定簇的抗体预处理胰岛可延长小鼠胰岛同种异体移植的存活时间。
Prolongation of murine islet allograft survival by pretreatment of islets with antibody directed to Ia determinants.
作者信息
Faustman D, Hauptfeld V, Lacy P, Davie J
出版信息
Proc Natl Acad Sci U S A. 1981 Aug;78(8):5156-9. doi: 10.1073/pnas.78.8.5156.
Abstract
Islets of Langerhans treated with donor-specific anti-Ia serum and complement were transplanted across a major histocompatibility barrier into nonimmunosuppressed diabetic mice. The allografts survived in all recipients for at least 200 days after transplantation. Rejection of an established allograft could be induced by intravenous injection of donor splenocytes. This demonstrates that allografts can serve as targets for immune rejection and supports the possible role of Ia-positive passenger lymphoid cells in initiation of immune rejection. The results show that immunosuppression of the recipient is not a prerequisite for successful transplantation.
摘要
用供体特异性抗Ia血清和补体处理的胰岛被跨越主要组织相容性屏障移植到未免疫抑制的糖尿病小鼠体内。同种异体移植物在所有受体中移植后至少存活200天。静脉注射供体脾细胞可诱导已建立的同种异体移植物发生排斥反应。这表明同种异体移植物可作为免疫排斥的靶标，并支持Ia阳性过客淋巴细胞在免疫排斥启动中的可能作用。结果表明，受体的免疫抑制不是成功移植的先决条件。
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