小鼠胰腺β细胞表达H-2K和H-2D，但不表达Ia抗原。
Murine pancreatic beta-cells express H-2K and H-2D but not Ia antigens.
作者信息
Faustman D, Hauptfeld V, Davie J M, Lacy P E, Shreffler D C
出版信息
J Exp Med. 1980 Jun 1;151(6):1563-8. doi: 10.1084/jem.151.6.1563.
Abstract
Direct microcytotoxicity testing and absorption analyses were employed to determine whether H-2K, H-2D, and Ia antigens are present on murine islet of Langerhans cells. Products of the H-2K and H-2D loci were found on beta-cells from three different mouse strains, but I-region (Ia) antigens were not detected. The absence of Ia gene products from islet cells may be of importance in explaining the survival of islet allografts across major histocompatibility barriers.
摘要
采用直接微量细胞毒性试验和吸收分析来确定小鼠胰岛朗汉斯细胞上是否存在H-2K、H-2D和Ia抗原。在来自三种不同小鼠品系的β细胞上发现了H-2K和H-2D位点的产物，但未检测到I区（Ia）抗原。胰岛细胞中Ia基因产物的缺失可能对解释胰岛同种异体移植跨越主要组织相容性屏障后的存活情况具有重要意义。
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