Domellöf L, Eriksson S, Mori H, Weisburger J H, Williams G M
Am J Surg. 1981 Nov;142(5):551-4. doi: 10.1016/0002-9610(81)90423-2.
Possible promotion of MNNG-induced gastrointestinal carcinogenicity was evaluated in male Wistar rats exposed to unconjugated bile acid given as gavage or as obtained through truncal vagotomy plus pyloroplasty. No significant difference was found compared with the relevant control groups. Even though gastroduodenal erosions were found more frequently in the bile acid gavage and MNNG groups than in MNNG-treated controls, secondary deconjugated bile acids apparently did not reach optimal promoting concentrations. In contrast to partial gastrectomy, vagotomy and pyloroplasty does not increase the tumor yield in the rat.
在接受经口灌胃给予的未结合胆汁酸或通过迷走神经切断术加幽门成形术获得的未结合胆汁酸的雄性Wistar大鼠中，评估了其对MNNG诱导的胃肠道致癌性的潜在促进作用。与相关对照组相比，未发现显著差异。尽管在胆汁酸灌胃组和MNNG组中比MNNG处理的对照组更频繁地发现胃十二指肠糜烂，但继发性去结合胆汁酸显然未达到最佳促进浓度。与部分胃切除术相反，迷走神经切断术和幽门成形术不会增加大鼠的肿瘤发生率。
