胸腺对免疫活性的产生及抗原特异性主要组织相容性复合体（MHC）限制的细胞毒性T淋巴细胞前体多样性的影响 - Suppr

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超能文献

Impact of thymus on the generation of immunocompetence and diversity of antigen-specific MHC-restricted cytotoxic T-lymphocyte precursors.

作者信息

Wagner H, Hardt C, Stockinger H, Pfizenmaier K, Bartlett R, Röllinghoff M

出版信息

Immunol Rev. 1981;58:95-129. doi: 10.1111/j.1600-065x.1981.tb00351.x.

DOI:10.1111/j.1600-065x.1981.tb00351.x

PMID:6796497

Abstract

摘要

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Impact of thymus on the generation of immunocompetence and diversity of antigen-specific MHC-restricted cytotoxic T-lymphocyte precursors.胸腺对免疫活性的产生及抗原特异性主要组织相容性复合体（MHC）限制的细胞毒性T淋巴细胞前体多样性的影响

Immunol Rev. 1981;58:95-129. doi: 10.1111/j.1600-065x.1981.tb00351.x.

Frequency analysis of cytotoxic T lymphocyte precursors in chimeric mice. Evidence for intrathymic maturation of clonally distinct self-major histocompatibility complex- and allo-major histocompatiblilty complex-restricted virus-specific T cells.嵌合小鼠中细胞毒性T淋巴细胞前体的频率分析。克隆性不同的自身主要组织相容性复合体和同种异体主要组织相容性复合体限制性病毒特异性T细胞胸腺内成熟的证据。

J Exp Med. 1981 Jun 1;153(6):1517-32. doi: 10.1084/jem.153.6.1517.

Development and loss of virus-specific thymic competence in bone marrow radiation chimeras and normal mice.骨髓辐射嵌合体和正常小鼠中病毒特异性胸腺能力的发育与丧失

Immunol Rev. 1981;58:37-72. doi: 10.1111/j.1600-065x.1981.tb00349.x.

Thymus dictates major histocompatibility complex (MHC) specificity and immune response gene phenotype of class II MHC-restricted T cells but not of class I MHC-restricted T cells.胸腺决定主要组织相容性复合体（MHC）的特异性以及II类MHC限制性T细胞的免疫反应基因表型，但不决定I类MHC限制性T细胞的免疫反应基因表型。

J Exp Med. 1984 Dec 1;160(6):1752-66. doi: 10.1084/jem.160.6.1752.

Self-MHC-restricted cytotoxic T-cell response without thymic influence.无胸腺影响的自身主要组织相容性复合体限制的细胞毒性T细胞应答。

Nature. 1981 Feb 5;289(5797):494-5. doi: 10.1038/289494a0.

Alloreactivity, the development of the T cell repertoire and the understanding of T cell function.同种异体反应性、T细胞库的发育以及对T细胞功能的理解。

Immunol Rev. 1978;42:20-59. doi: 10.1111/j.1600-065x.1978.tb00257.x.

Thymus and lymphohemopoietic cells: their role in T cell maturation in selection of T cells' H-2-restriction-specificity and in H-2 linked Ir gene control.胸腺与淋巴造血细胞：它们在T细胞成熟、T细胞H-2限制性特异性选择以及H-2连锁免疫反应基因控制中的作用。

Immunol Rev. 1978;42:224-70. doi: 10.1111/j.1600-065x.1978.tb00264.x.

The H-2 phenotype of the thymus dictates the self-specificity expressed by thymic but not splenic cytotoxic T lymphocyte precursors in thymus-engrafted nude mice.胸腺的H-2表型决定了胸腺移植裸鼠中胸腺而非脾脏细胞毒性T淋巴细胞前体所表达的自身特异性。

J Immunol. 1981 Nov;127(5):2168-76.

Intrathymic tolerance induction: determination of tolerance to class II major histocompatibility complex antigens in maturing T lymphocytes by a bone marrow-derived non-lymphoid thymus cell.胸腺内耐受诱导：骨髓来源的非淋巴细胞性胸腺细胞对成熟T淋巴细胞中II类主要组织相容性复合体抗原耐受性的测定

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H-2 restriction as a consequence of intentional priming. Frequency analysis of alloantigen-restricted, trinitrophenyl-specific cytotoxic T lymphocyte precursors within thymocytes of normal mice.作为有意致敏结果的H-2限制。正常小鼠胸腺细胞内同种抗原限制的、三硝基苯基特异性细胞毒性T淋巴细胞前体的频率分析。

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引用本文的文献

Lyt-23+ cyclophosphamide-sensitive T cells regulate the activity of an interleukin 2 inhibitor in vivo.Lyt-23+环磷酰胺敏感T细胞在体内调节白细胞介素2抑制剂的活性。

J Exp Med. 1981 Aug 1;154(2):262-74. doi: 10.1084/jem.154.2.262.

Functional clonal deletion of cytotoxic T-lymphocyte precursors in chimeric thymus produced in vitro from embryonic Anlagen.在由胚胎原基体外产生的嵌合胸腺中，细胞毒性T淋巴细胞前体的功能性克隆缺失。

Proc Natl Acad Sci U S A. 1983 May;80(10):3045-9. doi: 10.1073/pnas.80.10.3045.

Frequency of herpes simplex virus-specific cytotoxic T lymphocyte precursors in lymph node cells of infected mice.感染小鼠淋巴结细胞中单纯疱疹病毒特异性细胞毒性T淋巴细胞前体的频率

Immunology. 1984 Jan;51(1):57-64.

Frequency of cytotoxic T lymphocyte precursors to herpes simplex virus type 1 as determined by limiting dilution analysis.通过有限稀释分析确定的针对1型单纯疱疹病毒的细胞毒性T淋巴细胞前体的频率。

Infect Immun. 1983 Feb;39(2):785-92. doi: 10.1128/iai.39.2.785-792.1983.

Role of Ia antigen expression and secretory function of accessory cells in the induction of cytotoxic T lymphocyte responses against herpes simplex virus.辅助细胞Ia抗原表达及分泌功能在诱导针对单纯疱疹病毒的细胞毒性T淋巴细胞反应中的作用。

Infect Immun. 1982 Sep;37(3):1138-47. doi: 10.1128/iai.37.3.1138-1147.1982.

Primary T-cell responses to minor alloantigens. II. Analysis of accessory cell requirements for the development of cytotoxic T lymphocytes.针对次要同种异体抗原的初始T细胞应答。II. 细胞毒性T淋巴细胞发育所需辅助细胞的分析。

Immunology. 1983 Dec;50(4):555-63.

Impaired culture generated cytotoxicity with preservation of spontaneous natural killer-cell activity in cartilage-hair hypoplasia.在软骨毛发发育不全中，培养受损产生细胞毒性，同时自然杀伤细胞的自发活性得以保留。

J Clin Invest. 1983 Jun;71(6):1737-43. doi: 10.1172/jci110928.

Helper cells in the autologous mixed lymphocyte reaction. III. Production of helper factor(s) distinct from interleukin 2.自身混合淋巴细胞反应中的辅助细胞。III. 不同于白细胞介素2的辅助因子的产生。

J Exp Med. 1982 Dec 1;156(6):1807-20. doi: 10.1084/jem.156.6.1807.

Cytotoxic T lymphocyte responses in allogeneic radiation bone marrow chimeras. The chimeric host strictly dictates the self-repertoire of Ia-restricted T cells but not H-2K/D-restricted T cells.同种异体辐射骨髓嵌合体中的细胞毒性T淋巴细胞反应。嵌合宿主严格决定Ia限制性T细胞的自身 repertoire，但不决定H-2K/D限制性T细胞的自身 repertoire。

J Exp Med. 1982 Dec 1;156(6):1650-64. doi: 10.1084/jem.156.6.1650.

Self-recognition specificity expressed by T cells from nude mice. Absence of detectable Ia-restricted T cells in nude mice that do exhibit self-K/D-restricted T cell responses.裸鼠T细胞表达的自身识别特异性。在确实表现出自身K/D限制性T细胞应答的裸鼠中未检测到Ia限制性T细胞。

J Exp Med. 1984 Sep 1;160(3):839-57. doi: 10.1084/jem.160.3.839.

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